View abstract. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., and Wright, J. D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. View abstract. Gastroenterology 1989;97:1033-42. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Lutein is best absorbed when taken with a J.Matern.Fetal Neonatal Med. Stedman's Medical Dictionary. Calendula is often marketed as a treatment for eczema and dermatitis, but there is not much research supporting its effectiveness for these conditions. Williams, M. A., Woelk, G. B., King, I. 26th ed. View abstract. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Researchers at Harvard University have found that supplementing with lutein daily can lower the risk for macular degeneration. J Am Optom Assoc 1999;70:39-47. View abstract. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. View abstract. Slattery ML, Potter JD, Coates A, et al. Both older and younger people should consume plenty of lutein in order to reduce the risk of oxidative damage that can lead to disorders down the road. To preserve skin health and fight skin cancer, lutein helps filter high-energy wavelengths of visible light, which slows down the rate of oxidative stress. Am J Epidemiol 1998;148:204-14. Am J Clin Nutr 2000;71:1187-93. Am.J.Clin.Nutr. Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., and Ohno, Y. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. View abstract. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. View abstract. J Invest Dermatol 2004;122:510-7. Curran-Celentano, J., Hammond, B. R., Jr., Ciulla, T. A., Cooper, D. A., Pratt, L. M., and Danis, R. B. This raises the risk for arteriosclerosis development and clogging of the carotid arteries that can lead to heart attacks. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. It is thought to function as a light filter, protecting the eye tissues from sunlight damage. Always check with your doctor before you use a natural product. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. View abstract. View abstract. Kotagiri SR, Morde A, Rai D, et al. Cota F, Costa S, Giannantonio C, Purcaro V, Catenazzi P, Vento G. Lutein supplementation and retinopathy of prematurity: a meta-analysis. Majumdar SK, Shaw GK, Thomson AD, et al. Br.J Nutr 1999;82(3):203-212. Am J Clin Nutr 1998;68:82-9. Seddon JM, Ajani UA, Sperduto RD, et al. Our team aims to be not only thorough with its research, but also objective and unbiased. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. Perrone, S., Longini, M., Marzocchi, B., Picardi, A., Bellieni, C. V., Proietti, F., Rodriguez, A., Turrisi, G., and Buonocore, G. Effects of lutein on oxidative stress in the term newborn: a pilot study. View abstract. View abstract. View abstract. Studies done by the University of Southern California suggest that low levels of lutein within the blood might contribute to the thickening of artery walls. Dagnelie G, Zorge IS, McDonald TM. Astaxanthin supplementation does not attenuate muscle injury following eccentric exercise in resistance-trained men. Optom Vis Sci 1997;74:499-504. Clin.Exp.Optom. Bernstein PS, Li B, Vachali PP, Gorusupudi A, Shyam R, Henriksen BS, Nolan JM. View abstract. Ravindran, R. D., Vashist, P., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Jayanthi, R., John, N., Fitzpatrick, K. E., Chakravarthy, U., Ravilla, T. D., and Fletcher, A. E. Inverse association of vitamin C with cataract in older people in India. Long-term nutrient intake and early age-related nuclear lens opacities. JAMA Intern Med. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Vision Res. Invest Ophthalmol.Vis.Sci. With dry eye disease, also known as dry eye syndrome, your eyes dont make enough lubrication to coat your eyes. This can cause red, itchy, burning, eyes, temporary blurriness, and a feeling as if theres sand in your eye. According to a 2016 study, lutein may help reduce these symptoms. How much lutein do you need? J Aging Res 2019;2019:3709402. Int J Vitam Nutr Res 1998;68:360-5. Compared to the control group, diabetic rats taking the supplements experienced lower oxidative stress rates and less damage done to the retina of the eyes, despite being under hyperglycemic conditions. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. View abstract. Ophthalmologica 2017;237(3):159-66. View abstract. Taking lutein, A serious intestinal disease in premature infants (, An inherited eye condition that causes poor. 2002;74(3):371-381. Read Next: Top 7 Ways Carrot & Carrot Juice Benefit Your Body. View abstract. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., and Teppo, L. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Koonsvitsky BP, Berry DA, et al. Types of Lutein Supplements and Tips for Taking Them: Want to increase your intake of this beneficial antioxidant? Capeding, R., Gepanayao, C. P., Calimon, N., Lebumfacil, J., Davis, A. M., Stouffer, N., and Harris, B. J. Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety. Teikari JM, Virtamo J, Rautalahti M, et al. 2011;52(12):9207-9217. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. It occurs in certain algae and causes the pink-red color in salmon. Exp Eye Res 1997;65:57-62. 5 Reasons to Add Lamb Meat to Your Diet, St. Johns Wort Benefits for Depression, PMS & Menopause. Curr Dev Nutr 2021;5(10):nzab123. Vegetables, fruit, and cancer. 2002;56(7):615-621. View abstract. View abstract. View abstract. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Am J Epidemiol 1999;149:801-9. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. 2014;42(1):25-38. View abstract. Photochem.Photobiol. 2011;94(5):1211-1218. View abstract. 2012;22(2):216-225. Graefes Arch.Clin.Exp.Ophthalmol. Schupp C, Olano-Martin E, Gerth C, et al. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. 2-15-2007;458(2):128-135. At this time there isnt a general recommendation for daily intake of lutein or zeaxanthin. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Qiu Z, Chen X, Geng T, et al. View abstract. OTHER NAME(S): All-E-Lutein, Beta,epsilon-carotene-3,3'-diol, E-L. Lutein is found in many foods, including egg yolks, spinach, kale, corn, orange pepper, kiwi fruit, grapes, zucchini, and squash. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. View abstract. View abstract. View abstract. View abstract. Br J Nutr 2001;85(2):227-238. Valero, M. P., Fletcher, A. E., De Stavola, B. L., Vioque, J., and Alepuz, V. C. Vitamin C is associated with reduced risk of cataract in a Mediterranean population. Lai JS, Veetil VO, Lanca C, et al. This carotenoid is obtained from both foods and supplements, which are generally considered safe. 7-15-2001;391(2):160-164. BMC.Ophthalmol. View abstract. Teikari JM, Rautalahti M, Haukka J, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. View abstract. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Invest Ophthalmol.Vis.Sci. Yeum KJ, Ahn SH, Rupp de Paiva SA, et al. While we dont know exactly how lutein and cancer formation is tied just yet, correlational studies have shown that adults with higher levels of lutein in the blood experience a reduced risk of developing several forms of common cancers. Dietary modification of human macular pigment density. View abstract. View abstract. 1996;66(2):119-125. 2001;119(7):1009-1019. Yeum, K. J., Booth, S. L., Sadowski, J. Goodman, M. T., Kiviat, N., McDuffie, K., Hankin, J. H., Hernandez, B., Wilkens, L. R., Franke, A., Kuypers, J., Kolonel, L. N., Nakamura, J., Ing, G., Branch, B., Bertram, C. C., Kamemoto, L., Sharma, S., and Killeen, J. Nutrients. 2006;84(5):971-974. JAMA Ophthalmol 2015;133(12):1415-24. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. View abstract. Nutr Neurosci 2021. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. Natarajan, L., Rock, C. L., Major, J. M., Thomson, C. A., Caan, B. J., Flatt, S. W., Chilton, J. Mares-Perlman JA, Brady WE, Klein BE, et al. van den Berg H. Effect of lutein on beta-carotene absorption and cleavage. Johnson, E. J. Fitzgerald KC, O'Reilly J, Fondell E, et al. Am J Clin Nutr 2004;80:1508-20. Clin Cosmet Investig Dermatol 2016;9:325-332. Keep in mind that as with other antioxidants, people seem to differ in terms of how capable their bodies are of absorbing lutein. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. Serum antioxidants and age-related macular degeneration in a population-based case-control study. View abstract. Oncotarget 2017;8(2):2391-9. 2017;7:CD000254. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. Am J Clin Nutr 1999;70(4):490-494. WebLutein is one of two major carotenoids found in the human eye (macula and retina). Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. There arent any known special precautions for women who are pregnant or breastfeeding, but its always a good idea to speak with your doctor when pregnant before beginning new supplemental treatments. Richer S, Stiles W, Statkute L, et al. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. Loughman, J., Nolan, J. M., Howard, A. N., Connolly, E., Meagher, K., and Beatty, S. The impact of macular pigment augmentation on visual performance using different carotenoid formulations. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. If you suspect you might benefit from high doses of lutein, its best to speak with your doctor to rule out any potential contraindications. View abstract. Brown L, Rimm EB, Seddon JM, et al. 2004;13(8):1276-1282. View abstract. 2013 Feb 15;5(2):543-51. View abstract. Schunemann HJ, Grant BJ, Freudenheim JL, et al. Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Kaya, S., Weigert, G., Pemp, B., Sacu, S., Werkmeister, R. M., Dragostinoff, N., Garhofer, G., Schmidt-Erfurth, U., and Schmetterer, L. Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectance. BMC Ophthalmol 2007;7:3. 2015 Aug 25;314(8):791-801. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. Richer, S., Devenport, J., and Lang, J. C. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. View abstract. Int J Food Sci Nutr 2016;67(7):744-53. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. Coyne, T., Ibiebele, T. I., Baade, P. D., Dobson, A., McClintock, C., Dunn, S., Leonard, D., and Shaw, J. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. For people with a genetic predisposition to eye disorders or cancer, taking more lutein might be necessary. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. Kostic D, White WS, Olson JA. Wolf-Schnurrbusch UE, Zinkernagel MS, Munk MR, Ebneter A, Wolf S. Oral lutein supplementation enhances macular pigment density and contrast sensitivity but not in combination with polyunsaturated fatty acids. View abstract. Therapeutic Research Faculty 2020. This information may not fit your specific health circumstances. View abstract. Slattery ML, Benson J, Curtin K, et al. Machida N, Kosehira M, Kitaichi N. Clinical effects of dietary supplementation of lutein with high bio-accessibility on macular pigment optical density and contrast sensitivity: A randomized double-blind placebo-controlled parallel-group comparison trial. Chen F, Hu J, Liu P, Li J, Wei Z, Liu P. Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Vitamin D: 2 people, 18.18%. Central retinal thickness is positively correlated with macular pigment optical density. Nussbaum, J. J., Pruett, R. C., and Delori, F. C. Historic perspectives. Gruber M, Chappell R, Millen A, et al. 2002;132(12):3668-3673. J Alzheimers Dis 2022;90(1):233-249. View abstract. Reboul E, Thap S, Perrot E, et al. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Wet Age-Related Macular Degeneration and Vision Loss, An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). 2004;3(6):310-316. Although its best to get enough of this antioxidant naturally through a healthy diet high in anti-inflammatory foods, nutritional supplements or fortified foods and beverages can also be used by some people in order to help increase levels. Am J Clin Nutr 1997;66:366-72. 2014;52(4):198-205. View abstract. While the research is still in its early stages, taking lutein three times weekly for up to two years has been shown to improve vision in older people who already have cataracts. View abstract. View abstract. Arch Ophthalmol 1993;111:761-72. van den Berg H, van Vliet T. Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men. View abstract. J Nutr.Biochem. View abstract. What is the best eye vitamin for macular degeneration? Cancer Epidemiol.Biomarkers Prev. View abstract. Duncan, J. L., Aleman, T. S., Gardner, L. M., De Castro, E., Marks, D. A., Emmons, J. M., Bieber, M. L., Steinberg, J. D., Bennett, J., Stone, E. M., MacDonald, I. M., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in choroideremia. View abstract. Paetau, I., Rao, D., Wiley, E. R., Brown, E. D., and Clevidence, B. Ma L, Liu R, Du JH, et al. Ophthalmology 2002;109:2272-8.. View abstract. Am J Respir Crit Care Med 2001;163:1246-55.. View abstract. 2010;26(6):623-626. Cardinault, N., Gorrand, J. M., Tyssandier, V., Grolier, P., Rock, E., and Borel, P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. 2012;56(1):126-146. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. 2007;61(10):1180-1188. J Nutr 2022;152(11):2555-64. View abstract. Arch.Biochem.Biophys. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. It contains 20 mg of lutein, 4 mg of zeaxanthin, 408mg of vitamin C, 242.3mg of vitamin E, 30mg of zinc, and 1.5mg of copper. JAMA 2013;309(19):2005-2015. I. The answer will tell you how much lutein youre getting. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. 2012;90(5):e399-e403. Int.J.Vitam.Nutr.Res. View abstract. Ophthalmology 2003;110(1):51-60. A., Meyer-Wenger, A., Moser, U., Wright, A., Southon, S., Thurnham, D., Chopra, M., van den, Berg H., Olmedilla, B., Favier, A. E., and Roussel, A. M. No significant effects of lutein, lycopene or beta-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. 1997;78(5):775-784. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. View abstract. Am J Clin Nutr 2012;96(4):902-910. That is exactly why the lens needs to remain clear and free from the cloudiness that is indicative of cataracts. 22. Ophthalmology 2011;118(10):1958-1965. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. 2001;42(1):235-240. 2002;120(12):1732-1737. View abstract. 2000;71(3):239-245. Cancer Epidemiol Biomarkers Prev 2003;12:518-26. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). Cancer risk, and a feeling as if theres sand in your eye parenteral nutrition with branched-chain amino in... Capable their bodies are of absorbing lutein adult cystic fibrosis patients it occurs certain... Monozygotic twins the eye tissues from sunlight damage L, et al B. R., Jr., Fuld,,... Incident age-related nuclear cataracts in the Beaver Dam eye study retinal concentrations of Supplements! 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