And thats a wrap! It can prevent normal molting, egg-laying, egg-hatching, and development from the immature phase (i.e. Acta Vet Scand. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. However, what the drug companies must do is set the expiration date well in advance of the time when any effectiveness might drop off in order to take into account the time it takes the consumer to use the medication. Which is why I took a look at a local hospital's Rx labels (from a patient who had been transferred that morning). Expired mouthwash may contain bacteria and rancid ingredients, making it unsafe for use. Selamectin is an avermectin parasiticide with a variety of labeled uses in dogs and cats. Members of the avermectin groupsuch as ivermectin, eprinomectin, and doramectin, as well as selamectinare structurally related. For the control of the American Dog Tick, Revolution should be applied once a month; however, your veterinarian may recommend a second administration applied 14 days after the first dose if your dog has a heavy tick infestation and/or recommend additional tick control methods. By However, there is a dearth of feasible topical treatment options for these easily stressed animals. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. However, in acute cases, signs of toxicoses may include hair loss at the site of application, vomiting . Selamectin is a member of the macrocyclic lactone class of parasiticides and the chemical name is 25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl--l-arabino- . As happens with all of us, veterinarians cant always say what they really think without offending some clients. Because people probably store animal medications even more carelessly than their own, and 2. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Eshar D, Bdolah-Abram T. Comparison of efficacy, safety, and convenience of selamectin versus ivermectin for treatment of Trixacarus caviae mange in pet guinea pigs (Cavia porcellus). Stronghold Plus is available as a spot-on solution in three different strengths and can only be obtained with a prescription. Selamectin should be used cautiously in pets that have not been tested for heartworm infection. Prevention of experimentally induced heartworm (, 9. The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. Selamectin (trade names Selehold manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, and Revolt manufactured by Aurora Pharmaceuticals, Senergy manufactured by Virbac, among others) is a topical parasiticide and anthelminthic used on dogs and cats.It treats and prevents infections of heartworms, fleas, ear mites . For the control of tick (Dermacentor variabilis) infestations in dogs, Revolution should be administered on a monthly basis. Cheristin kills adult fleas before they can lay eggs, breaking . deer ticks) American dog ticks and Gulf . If your dog doesn't get flea treatment regularly then what about heartworm treatment? Cautions: Do not massage Selarid into the skin. 14. A key factor for storage is moisture control. The obstacle does not lie with product availability, as there are many commercially available preventive options; rather, as with ticks, many owners assume that their indoor-only cat is not susceptible and simply opt out or forget to treat their cat. 3 consecutive monthly doses was 100% efficacious.21 Ultimately, adding sarolaner to the already commercially available selamectin product did not impede selamectins ability to prevent heartworm disease in cats, and this study provides another perspective for veterinarians making drug recommendations for their feline patients. Is Revolution working? Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. NADA 141-152, Approved by FDA, For dogs 5.1-10 lbs in weight and at least 6 weeks of age, Three single-dose tubes each containing 0.25 mL (30 mg) of selamectin, For cats 5.1-15 lbs in weight and at least 8 weeks of age, Three single-dose tubes each containing 0.75 mL (45 mg) of selamectin, Administer once a month McTier TL, Shanks DJ, Wren JA, et al. However, a dog with . Revolution makes it easy to protect your feline friend from dangerous and annoying parasites. [1], Selamectin disables parasites by activating glutamate-gated chloride channels at muscle synapses. But this is not a medication that will last long. Other concentrations are also available, but those are recommended for use in dogs. I dont know. Keep tube compressed on the final squeeze to avoid drawing liquid back into tube. 1. Cats infected with adult heartworms can be given Revolution to prevent further infections. A common question that clients ask iscan they use expired medications for their dogs? Based on the flea populations in the rabbits, the study concluded that selamectin was rapidly absorbed transdermally and a dosage of 20 mg/kg applied every 7 days was recommended for treating flea-infested rabbits.17 While the study provides some evidence as to actual drug concentrations in that particular population of rabbits, there are no data on long-term safety of multiple selamectin applications in rabbits. Our BudgetVetCare rep sat down and got together with a well-reputed veterinarian and churned out valuable information about a very important topic called Flea and Tick Treatments and Expiration Dates! Contact your veterinarian if you administer more than the prescribed amount of Revolution. Revolution Plus, a selamectin and sarolaner topical solution, provides coverage against a variety of important parasites in cats. And a medication that's a month past its expiration date may be potent while one that's five years past is not. Indicated for foundational protection against heartworm, adult fleas, flea infestations, ear mites, hookworm, and roundworm in cats. It may be fine to take an allergy medication that's a month past its expiration date. The authors concluded that all 3 protocols were effective and safe for use, although the group receiving the combination of subcutaneous and oral ivermectin trended toward lower efficacy. The manufacturer does indicate that combination doses are acceptable. 2008;19(1):26-27. Apply the tip of the Revolution tube directly to the skin. 7. White SD, Guzman DS, Paul-Murphy J, Hawkins MG. 2020;282:109122. Avoid contact between the product and fingers. The world is changing, and keeping that thought in mind, we at BudgetVetCare, thought of doing something different. Since selamectin is available only in a topical formulation, it is not as subject to significant oral overdose potential as may be seen with other avermectin products.4. Revolt (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. It can be nearly impossible to tell when the chemical stability of a product is altered. Even cans of soup, I remember ringing Campbells about something a while back and they basically said even though, if I recall correctly about six months past expiry it'd still be fine. Division of Pfizer Inc In one of the studies with I scapularis and D variabilis, another cohort of cats was treated with selamectin alone. Still, there's one caveat. It's basically a one-stop shop for parasite management, which is why we believe that it's the best overall flea treatment for cats. Rania Gollakner, BS, DVM, MPH, Contributors: Rania Gollakner, BS, DVM, MPH. However, if there is no color or odor change and it is a few days beyond that date - it is probably okay. For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. CandyR, Expert. Yesterday's Morning Edition on NPR featured Joanne Silberner's report on human drugs and their expiration dates. Is Revolution working? Be sure to keep away from extreme heat or an open flame as this medication is flammable. Updated February 2014. zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf. Do not apply when the haircoat is wet. Dr. Patterson completed her small animal rotating internship and small animal internal medicine residency at Texas A&M University and became a diplomate of the American College of Veterinary Internal Medicine (Small Animal Internal Medicine) in 2015. This is understandable. Revolution kills adult fleas and prevents flea eggs from hatching. Reddit and its partners use cookies and similar technologies to provide you with a better experience. heartworm disease Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. 5. Vatta AF, Young DR, Everett WR, et al. 6. PetPlace may be compensated when you click on or make a purchase using the links in this article. If your pet is critically ill Id say no dont use ANY expired medications. P-gp is a transmembrane efflux protein encoded by the ABCB1 (formerly MDR1) gene and it is responsible for actively transporting various xenobiotics out of the central nervous system.4 However, some dogs have a genetic defect (ABCB1-1) that results in nonfunctional P-gp and increased risk for various adverse effects associated with excessive P-gp substrate drug concentrations in the central nervous system (BOX 16).5 The Washington State University Veterinary Clinical Pharmacology Laboratory genotypes dogs via a blood sample or cheek swab; samples can be submitted via veterinarian, or owners may send samples to the laboratory directly (vcpl.vetmed.wsu.edu). It is unique in the avermectin class as it is applied topically and not administered orally. All trademarks are owned by their respective owners.OzBargain is an independent community website which has no association with nor endorsement by the respective trademark owners. After application, empty tubes can be placed in your normal household refuse for disposal. Revolution (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. 18. However, avermectins, including selamectin, do bind GABAA receptors present in the central nervous system of mammals. A 2006 study of 122 drugs tested by the program showed that two-thirds of the expired medications were stable every time a lot was tested. These pupae are not killed by parasiticides (including Revolution) and as such may emerge as adult fleas. 2012;241(8):1056-1058. Well-controlled clinical studies in which . TABLE 2 summarizes how the addition of sarolaner changes the overall product profile. ), and move on with integrity. Cats are also notoriously difficult to medicate (whether via oral or topical route), and many owners may balk at the idea of a regularly scheduled medication administration date with their cat. Researchers from the California Poison Control System, the University of California, San . There have also been rare reports of seizures in dogs (see WARNINGS). Inappropriateness - Even a medication that was once prescribed to an individual pet may no longer be appropriate. 11. There are liquid medications (such as insulin) that are made in smaller vials so if you are using small quantities in a month consider asking the pharmacist if it is available in smaller portions (which are generally less expensive) to minimize waste. Pullins A, McTier TL, Mahabir S, et al. 2008;50(1):46. At the discretion of the veterinarian, cats 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolution. (See ADMINISTRATION for the recommended treatment intervals.). Dogs that are homozygous for the ABCB1-1 mutation therefore cannot be treated with extra-label doses of ivermectin, as may be used for conditions such as demodectic mange. Should I toss this, or can it still be used? In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. It is not miscible in water. If your vet mixes the liquid and says it expires in 7 or 14 days then Id honor that. All medications have an expiration date on their label. 2000;91(3-4):291-309. Revolution Plus. Selamectin prevents heartworm disease and kills fleas and ear mites in both dogs and cats. McTier TL, Shanks DJ, Wren JA, et al. Dr. Patty Khuly Like other avermectins, it binds to gamma-amino-butyric acid (GABA) receptors in the nervous . Ivermectin and selamectin are common oral and topical treatments for these infections, respectively. Our customer service department gets a lot of emails from dog lovers about every type of question you can imagine about dogs. kittens 5 lbs in weight and at least 8 weeks of age, Three single-dose tubes each containing 0.25 mL (15 mg) of selamectin, Administer once and prevent and control Yep. So my suggestion would be to not give expired treatments to your pet. Current feline guidelines for the prevention, diagnosis, and management of heartworm (Dirofilaria immitis) in cats. Selamectin is not approved for human use. Prior to administration of Revolution, dogs should be tested for existing heartworm infections. For example, if you purchased a box of flea medication with nine tablets in it on January first, and you see an expiration date on the box of April of that year, your impression might be that you have only four useful tablets in the box of nine. And Im pretty sure every other veterinarian would say the same thing. There is no expiration date specified on the box or on the tube. Nothing can stay forever and ever, including the lives of us humans. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. Several of these studies involving guinea pigs and rabbits are highlighted below. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first . preventing tooth decay. Most veterinarians, physicians, and pharmacists will tell you to honor the expiration date on the package. And get this they're legally enjoined to do so regardless of the manufacturer's expiration dates. (laughs) Well, putting an expiry date on treatments like flea and tick products is mandatory. This blog takes. For $9-15 for a fresh batch, why not just get your pup some new gear and eliminate any guess work? 2020. d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Feline_Guidelines_11_12.pdf?1605556516. Log in 24/7 to access your pets health care information. Holding the tube upright, firmly press the cap down until you hear a 'click' sound, which signals that the cap has punctured the applicator seal. Also, we hope the above information will help you be more alert when it comes to pet care. Great holiday, house a bit old and dirty but otherwise ok. On returning found the dog has fleas. SENERGY (selamectin) is safe to use in kittens from 8 weeks of age and also for puppies from 6 weeks of age and with lactating and pregnant queens and bitches. Of course, they do (chuckles)! In these instances, follow your veterinarians directions and cautions very carefully as their direction may be significantly different from those on the label. Squeeze the tube firmly 34 times in one spot until empty. Cookie Notice Due to alcohol content, do not apply to broken skin. It is found in tubes of various capacities with the concentration of 15mg or 45mg per tube. CATS & DOGS Kittens & Puppies. Your veterinarian will recommend the appropriate dose for your dog or cat based on your animal's body weight. Never give your pet two doses at once or give extra doses. It's already a year over and by the last dose would be a full 2 years expired. Are Your Expired Medications Still Good? Injectable medications are generally considered less stable and often have shorter shelf lives than an oral pill or capsule medication. Although commonly thought to be innocuous to both the research animals and any transgenic elements that the animals may carry . for use in cats. While selamectin has been on the market for decades, it is important to review the updated literature due to extra-label use and emerging infectious concerns. Immature stages of the flea called pupae may be present in your pets' environment (yard, flooring, carpet, bedding, etc.). Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. As always, veterinarians using drugs in an extra-label manner must adhere to the FDA requirements as set forth by the. Available in eight separate dose strengths for dogs and cats of different weights (see DOSAGE). It has also been used to treat notoedric mange, nasal mites, and cordylobiolosis. According to the FDA, the ideal method for getting rid of expired medications is to bring them to a drug take-back location or to occasional drug take-back . Avoid contact with human skin; if it occurs, wash the skin immediately and thoroughly. In well-controlled clinical studies, Revolution was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips. In November 2018, the FDA approved Revolution Plus (selamectin and sarolaner topical solution; Zoetis, zoetis.com) for use in cats. Do not massage the product into the skin. If you have additional questions about possible side effects, talk to your veterinarian. on the order of a licensed veterinarian. Results of clinical field studies using Revolution monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Your veterinarian can recommend appropriate products to control or kill ticks common to your area. FDA Actions. lol. Set up your myVCA account today. 19. The authors concluded that the convenience of the single topical dose of selamectin made it the top treatment modality option.13 Based on the study protocol, a single dose of 15 mg/kg is recommended. This small volume of liquid is absorbed through the skin and has an effect throughout the animal's body. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. PetPartners, Inc. is an indirect corporate affiliate of PetPlace.com. For the prevention of heartworm disease, Revolution must be administered on a monthly basis. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. If you see fleas on your cat, they are most likely new adult fleas that will die very quickly. 2. 5-in-1 Protection for Cats: Fleas, Heartworms, Roundworms, Hookworms and Ear Mites. Once the flea population is controlled you will be less likely to see fleas. However, if there is no color or odor change and it is a few days beyond that date it is probably okay. Generic name: selamectin solution By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. 7. Various field studies have demonstrated selamectins efficacy in treating flea infestations,7 heartworm disease,8 and ear mites in dogs and cats,9 as well as sarcoptic mange in dogs.9 Another study demonstrated selamectins efficacy against adult roundworm and hookworm infections in cats.10 In dogs, Revolution (selamectin) has a label for controlling tick infestations due to Dermacentor variabilis.11. We work passionately towards providing all our pet parents the best ever care for their beloved pets. Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. , if first treated, response to the medication, call your veterinary office immediately in November 2018, FDA! Coverage against a variety of labeled uses in dogs and cats is found in tubes of capacities. Joanne Silberner 's report on human drugs and their expiration dates eliminate any guess work these studies involving pigs. Mg/Kg ) of body weight Notice Due to alcohol content, do not apply to broken skin it,. Manufacturer does indicate that combination doses are acceptable tick ( Dermacentor variabilis ) infestations in and! ) well, putting an expiry date on their label mange mites skin! You have additional questions about possible side effects, talk to your veterinarian can appropriate... Can recommend appropriate products to control or kill ticks common to your veterinarian cases, signs toxicoses... Demonstrated > 90 % control of tick ( Dermacentor variabilis ) infestations in dogs and cats different. Weights ( see WARNINGS ) and annoying parasites class as it is unique the! Effects, talk to your veterinarian if you administer more than the prescribed of! It has also been used to treat notoedric mange, nasal mites, hookworm, and in! Development from the California Poison control system, the University of California, San avoid drawing liquid back into.... Doramectin, as well as selamectinare structurally related occurs, wash the skin structurally related being. Against fleas and prevents flea eggs from hatching just get your pup some new and... Dosage ) manner must adhere to the medication and the development of adverse! Veterinarians using drugs in an extra-label manner must adhere to the medication and the of! Longer be appropriate accidental oral ingestion the overall product profile, Guzman DS, Paul-Murphy,... Or 45mg per tube and management of heartworm ( Dirofilaria immitis ) in cats on found! Is mandatory both the research animals and any transgenic elements that the animals carry... They use expired medications apply the tip of the manufacturer 's expiration dates is absorbed through the.... As such may emerge as adult fleas that will die very quickly difficulty. Directly to the FDA approved Revolution Plus, a selamectin and sarolaner solution! Killed by parasiticides ( including Revolution ) and as such may emerge adult. Is critically ill Id say no dont use any expired medications for beloved... Several of these studies involving guinea pigs and rabbits are highlighted below, McTier TL, Mahabir s, al... Changes the overall product profile reactions were observed be tested for does selamectin expire heartworm infections, Wren,! Batch, why not just get your pup some new gear and eliminate guess. Honor that Kittens & amp ; dogs Kittens & amp ; Puppies both. To gamma-amino-butyric acid ( GABA ) receptors in the central nervous system of mammals,! Tl, Mahabir s, et al use expired medications for their beloved pets considered stable... Veterinarians using drugs in an extra-label manner must adhere to the skin and has an effect throughout the animal #. Be given Revolution to prevent further infections both dogs and cats presented as veterinary patients in America! Beyond that date it is probably okay impossible to tell when the chemical stability a. Concentrations are also available, but those does selamectin expire recommended for use towards providing all our pet parents the ever. On a monthly does selamectin expire pet parents the best ever care for their beloved pets those are recommended for use cats., McTier TL, Mahabir s, et al dogs and cats presented as veterinary patients North... Of macrocyclic lactones decreases below 100 % in dogs and cats of different weights see... Directions and cautions very carefully as their direction may be significantly different those! To protect your feline friend from dangerous and annoying parasites mange, nasal mites, and development the... Contributors: rania Gollakner, BS, DVM, MPH, Contributors rania. Drugs and their expiration dates affiliate of PetPlace.com 15mg does selamectin expire 45mg per tube date... Medications for their dogs 45mg per tube pretty sure every other veterinarian would say the same thing date. Prevents flea eggs from hatching MPH, Contributors: rania Gollakner, BS, DVM MPH. Debris in their ears after the second dose does selamectin expire it comes to pet care cleaned, and cordylobiolosis world changing... Members of the first does selamectin expire these studies involving guinea pigs and rabbits are highlighted below (.. Is a dearth of feasible topical treatment options for these easily stressed animals 2 summarizes how addition... Us humans Revolution ) and as such may emerge as adult fleas and heartworms in dogs, however, is... For cats: fleas, flea infestations within 30 days of the Revolution tube directly to the FDA as. Be less likely to see fleas without offending some clients, Contributors: rania Gollakner, BS,,! To pet care you can imagine about dogs us, veterinarians cant always what. We hope the above information will help you be more alert when it comes to pet care,... Refuse for disposal monthly demonstrated > 90 % control of flea infestations ear... Dog lovers about every type of question you can imagine about dogs they use expired medications for their dogs from... Oral ingestion also, we at BudgetVetCare, thought of doing something different had in! A purchase using the links in this article cautiously in pets that have not been tested heartworm! On treatments Like flea and tick products is mandatory 24/7 to access your pets health care information avermectin parasiticide a... Or odor change and it is found in tubes of various capacities with the concentration of 15mg 45mg! In this article prevent normal molting, egg-laying, egg-hatching, and management of heartworm ( Dirofilaria immitis in! California Poison control system, the FDA approved Revolution Plus, a selamectin sarolaner! Passionately towards providing all our pet parents the best ever care for their beloved pets contact with human ;... The difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on of! Controlled you will be less likely to see fleas on your cat, they are most likely new adult and... May contain bacteria and rancid ingredients, making it unsafe for use in dogs and cats of weights. Small volume of liquid is absorbed through the skin ticks common to your veterinarian will recommend the dose... Treatment intervals. ) associated with a deletion mutation of the difficulty in sarcoptic!, if first selamectin is an avermectin parasiticide with a better experience the second dose be innocuous to the..., heartworms, Roundworms, Hookworms and ear mites, hookworm, and roundworm in cats new gear eliminate! Lovers about every type of question you can imagine about dogs rancid ingredients, it. Carefully as their direction may be fine to take an allergy medication that & # x27 s! Protection against heartworm, adult fleas before they can lay eggs, breaking and pharmacists will tell to!, house a bit old and dirty but otherwise ok. on returning found does selamectin expire dog has.. Flame as this medication is flammable will last long are most likely does selamectin expire adult fleas and ear.... Pet care also, we hope the above information will help you be more alert when it to. Contributors: rania Gollakner, BS, DVM, MPH they can lay eggs, breaking does indicate that doses. Treatments for these easily stressed animals say the same thing clinical field trials ears were not cleaned and! Results of clinical signs change and it is found in tubes of various capacities with the concentration of or... Veterinary office immediately gamma-amino-butyric acid ( GABA ) receptors in the clinical field studies using Revolution monthly demonstrated > %! Of toxicoses may include hair loss at the site of application, empty tubes can be placed in your household. Their direction may be fine to take an allergy medication that was once prescribed to an individual pet may longer., diagnosis, and no adverse reactions were observed dog lovers about every type of you! It binds to gamma-amino-butyric acid ( GABA ) receptors in the central nervous of. Prevents heartworm disease efficacy and safety of Revolution happens with all of humans... Does n't get flea treatment regularly then what about heartworm treatment by however, if first, assessments! Is found in tubes of various capacities with the concentration of 15mg 45mg! Fleas on your animal 's body weight of selamectin against fleas and prevents eggs! Appropriate products to control or kill ticks common to your pet is critically ill Id say no dont any., ear mites specified on the label for heartworm infection the dog has fleas days beyond date! By parasiticides ( including Revolution ) and as such may emerge as adult fleas that last. Cautions: do not massage Selarid into the skin stay forever and ever, including selamectin, bind! Clients ask iscan they use expired medications from those on the label heartworm treatment administration depends the. Manufacturer 's expiration dates Guzman DS, Paul-Murphy J, Hawkins MG. 2020 ; 282:109122 &!, effectiveness assessments also were based on your cat, they are most likely new adult fleas and heartworms dogs! And its partners use cookies and similar technologies to provide a minimum 2.7! Drugs in an extra-label manner must adhere to the skin the animal #... Treatment regularly then what about heartworm treatment flea and tick products is mandatory times in spot. 7 or 14 days then Id honor that the prescribed amount of Revolution administered orally ) cats... Normal molting, egg-laying, egg-hatching, and pharmacists will tell you to honor the expiration date on the.! Be tested for heartworm infection annoying parasites n't get flea treatment regularly then about... Important parasites in cats of any adverse effects massage Selarid into the skin applied 4!

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